Chlorinized and ozonized topical remedy and process of making same



Aug. 13, 1929. B. E. CLARKE- CHLORIIZED AND OZONIZED TOPICAL REMEDY AND PROCESS OF MAKING SAME Filed DSC. l0, 1925 2 Sheets-Sheet www Aug., i3, 11923,

B. E. CLARKE CHLORINIZED AND OZONIZED TOPICAL REMEDY AND PROCESS 0F MAKING SAME Fil-ed Deo. 10, 1925 2 Sheets-Sheet mw QN M QN mm Panam aug. ia, 192ea BRUCE E. CLARKE, QF KANSAS CITY, MISSOURI.

CMQBDJIZED AND-OZONHED TOPIGL REMEDY AND PROCESS 0F MAKING SAME.

applmaanm mea neeember'io, ma serial no. vaast.

This invention relates to a topical remedy for human use, and is based upon the dis-V covery that ozone and chlorine, each of which has heretofore been recognized as being of therapeutic and germicidal value in the treatment of diseased tissues, will, if used conjointly for such purposes, have an' eect which'is greater than the mere individualeiiects of the two ingredients, in that lo the chlorine acts upon the diseased parts in a manner to repare the same for or render them especia y susceptible to the effects lof the oxygen and ozone. That is to say, the chlorine, acting upon, forinstance, tissues of the respiratory passages which are infected with cold, ilu and other germs, has the e'ect of stimulating the flow of lymph and cleansing the mucous surfaces wh1ch in turn causes the organisms to come to the surfaces and within reach of the ozone, which thereupon produces its effect of oxidation and destruction of the germs; this effect being in addition to the known germicidal effect of chlorine. More s ecically stated, chlorine acts as a powerfu germicide on account of its ainity for hydrogen and the consequent release of nascent oxygen when it comes into contact with micro-organisms in a moist condition but the amount of this o gen is limited." ence, by combining ozone 'rectly with the chlorine the eiiiciency of each gas is materially increased.

The object of the invention is to develop a to ical remedy which can be conveniently a5 mampulated and locally applied and whic will act, when heated either by the temperature of the surfaces to which applied or by tha a lication of extraneous heat, to liberate c orine and ozone or oxygen, or both, 40 in uncombined form against the surfaces to be treated; to which end, one feature of the invention consists in treating a suitable vehicular element, for instance, a fatty base A material of oil or viscous consistency, such as sweet oil, cocoal butter, cocoanut oil, or other vegetable fats, vaseline, or other like mineral fats, lard orother animal fats, and in short, any carbohydrate that is suitable ier use as a topical remedy or vehicle for a topical remedy, and which will not react chemicall with ozone and chlorine-to produce derivitives thereof, as distinguished from bearing these gases in free state; and treating such a vehicular element in a manner to develop molecular adhesion of the gas to the vehicle,

for instance, b thorou hl im re atin the vehicle withythe gase vghile ighegwilehicl is at a temperature'which renders extreme subdivision practicable, and while it is being thoroughly agitated and' subjected to bornbardmentv by the gases. By the expression uncombined, or free chlorine and ozone, the ap licant means that both chlorine and ozone iberate nascent oxygen as a product of their reaction, which liberation of Anascent oxygen from ozone greatly enhances the action of the nascent oxygen liberated by chlo- I rine alone.

Another feature of the invention resides in a topical remedy consisting of a vehicular element of the kind described together with the two gases, chlorine and ozone or oxygen, or both, incorporated therewith in uncombined state and under conditions which release them for reaction with the parts to be treated, when the vehicle is melted by the heat of the surfaces to which the remedy is applied; or, if preferred, is subjected to extraneous heat suiiicient to release the gases by ehullition. While ozone in free state is preferable as the oxidizing agent, oxygen in `uncombined state may beemployed with appreciably beneficial results. Hence, the mention of either oxidizing element herein is to be taken as including the other such element, or both of them. s

In order that the invention may be fully understood, an illustrative method of procedure will be described in detail, in connection with the accompanying drawings, in which apparatus suitable for practicing the process is schematically shown.

In said drawings- Figure 1 is a layout of. a complete set of apparatus including means for purifying, heating, and drying air for use as-a diluent, means for mixing -such repared air with chlorine and ozone in' pre etermined proportions, and meansfor maintaining a vehicular element at a temperature suitableoto facilitate its agitation and subdivision, and permeating the same with the mixture of air, chlorine, and ozone and causing the chlorine and ozone to be incorporated therewith.

Fi re 2 is a vertical section of an air scrub er;

Figure 3 is a similar view of an air heater;

Figure 4 shows in vertical section an air drier and means for mixingair sup lied therefrom with chlorine and ozone; and u.

Figure 5 is a vertical sectional view of a water jvacketed mixing tank suitable for mcorporating the chlorine and ozone gases, diluted with air, in the carbohydrate vehicle. v

Referring to' the drawings in detail, 1 represents an air scrubber containing a body 2 of water or other cleansing liquid, and communicating with atmosphere through means of a submerged spray bulb 3 andypipe 4, which latter has its outer end protected by a strainer 5 of approved construction, such, for instance as a covering of silk protected by wire gauze; the effect 1n said scrubber l being to admit air in inely subdivided streams into the lower portion of a body of water 2, whenever there is a sufficient drop of internal pressure in the scrubber due to suction on its outlet pipe 6. 7 represents an air compressor operated by amotor 8 having its suction port or intakevccnnccted with the pipe 6 leading from the scrubber 1, and having a pipe 9 through which it discharges purified air under pressure, leading to a storage tank 10. Discharge pipe 11 leading from air storage tank 10 discharges through a coil 12 (Figure 3) in a heater 13 where the air under compression is heated to a temperature which will render it more readily dried, and from the heater 13 the air passes through a pipe 14 to a drier 15 of known construction, such, for instance, as shown in Figure 4, wherein 15 represents the shell of the drier equipped with hygrometers 15, 15b and 16, 17 represent shelves arranged as bullies over which the air must take a circuitous course in reaching the air outlet, and upon which bellies a suitable moisture-absorbing substance is placed, for instance, quicklime, or a mixture of sodium carbonate and limey repared in a known manner to render it e cient as an absorbent of moisture. From the -drier 15 air under pressure, heated and dried, passes by wa of a pipe 18 to a gas mixing tank k19. his tank, as shown in Figure 4, receives hot dry air through a'jet nozzle 20, chlorine in uncombined form through a pipe 21 and atomizing bulb 22, and ozone through a pipe 23. Such gasv mixing tank also contains an agitator 24, preferably near the bottom and designed to have the effect of maintaining -internal circulation of suiciently violent form to insure thorough Vmingling of the chlorine and ozone and dilution of thev same with the admitted air. From the gas mixing tank 19, the mixture of air, chlorine, and ozone passes by way of pipe 25 vto a closed incorporatingv 'chamber 26 where the gases chlorine and ozone, which are to be incorporated in the vehicular element and which are borne upon the diluent body of air, are caused to thoroughly mingle with the vehicular element until they latter becomes corporating tank 26 has a heating jacket 27 for hot water .or steam, as may e desired through means of which the temperature ci the tank is ke t at a degree which renders the vehicular e ement best suited for saturation by the gases to be incorporated therewith; and in order that the gases may be caused to thoroughly permeate all parts of the body of melted ve icular element within the tank, the mixture of air and gases passes to the bottom of the tank and is there liberated in minute and numerous streams of subdivision through means of the spray device 28. Further than this, the incorporating tank-26 is equipped with an agitator 29 which keeps the heated vehicle in circulation and thus brings all parts thereof alike under the influence of the impregnating gases. Tank 26 being 'acketed for main'-A tenance of temperature v as its heating element, for instance, steam, regulated by a thermostatically controlled valve 27A of any suitable known construction.

Scrubbing the air removes the impurities carried in-suspension therewith, while d ing it removes the moisture which wou d otherwise react with the uncombined chlorine to produce hydrochloric acid and render the product objectionable both for therapeutic reasons and by reason of edect upon the fatty vehicle. Heating the air Jfacilitates thorough commingling of 'the gases therewith, and keeping the air under pressure facilitates the ultimate incorporation of the gases with the vehicle.

The admission of chlorine and ozone to the gas mixing chamber 19 will be regulated so as to make the chlorine in the proportion oi from .015 to .02 milligrams of chlorine to one liter of air or a proximately, one part chlorine to one hun red thousand parts of air; and the ozone in the proportion of one part of ozone to twenty thousand parts of air. In pro ortioning the active principles of the pr uct, namely, the chlorine and .ozoneA gases to the vehicular element, the lat-Y ter will be charged into the incorporating tank 26 in such quantity as will admit of thorough agitation and the provision of a reasonable expansion space over the mass, and the gases with theirair diluent will be charged into the incor orating tank for such length of time as will e found by experience to develop saturation of the vehicle with the gases chlorine and ozone. As one suitable carbohydrate or fatty vehicle for producing the article and practicing the process herein taught vaseline 1s suggested, and this is .particularly desirable as a vehicle when the product is to be applied locally, since the heat of the suraces to which it is applied melts the vehicle and so releases theactive be treated. But other vehic es melting under saturated with the chlorine and ozone. Inbody temperatures, for `instance, cocoa butter, lard, etc. ma be employed; or, for some purposes, vehic ar elements that stand in a state ci fusion at .normal atmospheric temperatures may be em lo ed. Hence, it is to he understood that t e invention is not limited to the use of any particular vehicular element. Nor is the invention limited to use with a vehicular element that is applied to theparts to be treated. Preparation may be made of a kind in which the active ingredients are driven od from the vehicle by the application of extraneous heat, conveyance lof the active principle to the surfaces to be treated heing through inhalation or otherwise, and being facilitated in some instances by volatilization of a portion of the vehicle itseli 'so as to deposit some of the vehicle upon the surfaces and thus coniine the active principle of tlie remedy to the surfaces until it has time to react.

Among other important advantages at tained by the use of the product of the pres- 1. As a new article of manufacture, a i

topical remedy, consisting of a vehicular element, and chlorine and a gas capable of producing nascent oxygen incorporated therewith.

' 2. As a new article of manufacture, a

fatty vehicular element having chlorine and ozone incorporated therewith.

3. As a new Aarticle of manufacture, a topical remedy, consisting of a vehicular element, and chlorine and ozone, both in uncombined form, incorporated therewith.

4. As a new article of manufacture, a topical remedy, consisting of a fusible yehi'cular element having chlorine and ozone incorporated therewith.

5. The method of producin a chlorinizing and oxidizing ltoplcal reme y, which consists in mixing oxygen and chlorine elements in uncombined form. with a diluent body of air, and then permeatin a vehicular elementL with a mixture of air, c lorine s and oxygen-producing gas vand causing t e said gases to become incorporated in their uncombined state with the vehicular element.

6. rlhe method of producing a chlorinizing andV oxidizing topical remedy, which consists in mixing dry heated air with uncombined chlorine and ozone, thoroughl mingling the mixture of air, lchlorine an ozone with a vehicular element while the latter is in fused state, and causing the chlorine and ozone in their uncombined state to become incorporated with said vehicular Aelement.

Signed at Chicago, Illinois, this 3rd day of December, 1925.

' BRUCE E. CLARKE... 

